EMD-70782

Single-particle
2.59 Å
EMD-70782
3D View Gallery
Deposition: 22/05/2025
Map released: 19/11/2025
Last modified: 25/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70782

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

DDB1-CRBN[Closed] with lenalidomide and SB-405483- consensus refinement

EMD-70782

Single-particle
2.59 Å
EMD-70782
3D View Gallery
Deposition: 22/05/2025
Map released: 19/11/2025
Last modified: 25/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: DDB1(BPB deleted)-CRBN complex with lenalidomide and SB-405483

Deposition Authors: Rizvi Z , Lander GC
Identification of an allosteric site on the E3 ligase adapter cereblon.
Dippon VN , Rizvi Z , Choudhry AE, Chung CW , Alkuraya IF, Xu W , Tao XB , Jurewicz AJ, Schneck JL , Chen W, Curnutt NM , Kabir F, Chan KH , Queisser MA , Musetti C, Dai H, Lander GC , Benowitz AB , Woo CM
(2026) Nature , 651 , 482 - 490
PUBMED: 41565821
DOI: doi:10.1038/s41586-025-09994-w
ISSN: 1476-4687
ASTM: NATUAS