EMD-70721

Single-particle
3.3 Å
EMD-70721
3D View Gallery
Deposition: 19/05/2025
Map released: 13/05/2026
Last modified: 03/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70721

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9opq summary report (pdf.gz) Map-9opq FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

TMPRSS2 (S441A) bound to the HCoV-NL63 S2'region genetically fused to the HCoV-HKU1 RBD

EMD-70721

Single-particle
3.3 Å
EMD-70721
3D View Gallery
Deposition: 19/05/2025
Map released: 13/05/2026
Last modified: 03/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Human coronavirus HKU1
Sample: TMPRSS2 (S441A) bound to the HCoV-NL63 S2'region genetically fused to the HCoV-HKU1 RBD
Fitted models: 9opq

Deposition Authors: McCallum M , Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler D
TMPRSS2-mediated coronavirus spike activation and inhibition.
McCallum M , Case JB , Brown JT, Park YJ , Lee J, Sutherland E , Aggarwal A, Gibson C, Lempp FA , Stewart C , Tortorici MA , Sanapala S, Low JS, Asarnow D , Bohan D , Dellota Jr E, Merz B, Chawla B, Kar S, Lanzavecchia A , Sallusto F, Riley NM , Turville S, Purcell L, Diamond MS , Veesler D
(2026) Nat Struct Mol Biol , 33 , 810 - 823
PUBMED: 42050172
DOI: doi:10.1038/s41594-026-01801-y
ISSN: 1545-9985
Grant Support: