EMD-70721

Single-particle
3.3 Å
EMD-70721
3D View Gallery
Deposition: 19/05/2025
Map released: 13/05/2026
Last modified: 03/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70721

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9opq summary report (pdf.gz) Map-9opq FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

TMPRSS2 (S441A) bound to the HCoV-NL63 S2'region genetically fused to the HCoV-HKU1 RBD

EMD-70721

Single-particle
3.3 Å
EMD-70721
3D View Gallery
Deposition: 19/05/2025
Map released: 13/05/2026
Last modified: 03/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Human coronavirus HKU1
Sample: TMPRSS2 (S441A) bound to the HCoV-NL63 S2'region genetically fused to the HCoV-HKU1 RBD
Fitted models: 9opq

Deposition Authors: McCallum M, Seattle Structural Genomics Center for Infectious Disease (SSGCID), Veesler D
TMPRSS2-mediated coronavirus spike activation and inhibition.
McCallum M, Case JB, Brown JT, Park YJ, Lee J, Sutherland E, Aggarwal A, Gibson C, Lempp FA, Stewart C, Tortorici MA, Sanapala S, Low JS, Asarnow D, Bohan D, Dellota Jr E, Merz B, Chawla B, Kar S, Lanzavecchia A, Sallusto F, Riley NM, Turville S, Purcell L, Diamond MS, Veesler D
(2026) Nat Struct Mol Biol , 33 , 810 - 823
PUBMED: 42050172
DOI: doi:10.1038/s41594-026-01801-y
ISSN: 1545-9985
Grant Support: