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EMD-70612
Cryo-EM structure of neddylated PCMTD1-ELOBC-CUL5-RBX2 (N8-CRL5-PCMTD1)
EMD-70612
Single-particle9.72 Å
Deposition: 13/05/2025Map released: 04/06/2025
Last modified: 03/12/2025
Sample Organism:
Homo sapiens,
Mus musculus
Sample: Neddylated complex of PCMTD1, Elongins B and C, Cullin-5, and RING-box protein 2 (N8-CRL5-PCMTD1)
Fitted models: 9omf
Deposition Authors: Pang EZ, Zhao B, Flowers C, Oroudjeva E
,
Winters JB,
Pandey V,
Sawaya MR
,
Wohlschlegel W,
Loo JA,
Rodriguez JA,
Clarke SG
Sample: Neddylated complex of PCMTD1, Elongins B and C, Cullin-5, and RING-box protein 2 (N8-CRL5-PCMTD1)
Fitted models: 9omf
Deposition Authors: Pang EZ, Zhao B, Flowers C, Oroudjeva E
,
Winters JB,
Pandey V,
Sawaya MR
,
Wohlschlegel W,
Loo JA,
Rodriguez JA,
Clarke SG
Structural basis for L-isoaspartyl-containing protein recognition by the human PCMTD1 cullin-RING E3 ubiquitin ligase.
Pang EZ,
Zhao B,
Flowers C,
Oroudjeva E
,
Winter JB,
Pandey V,
Sawaya MR
,
Wohlschlegel J,
Loo JA,
Rodriguez JA,
Clarke SG
(2025) J Biol Chem , 301 , 110735 - 110735
,
Winter JB,
Pandey V,
Sawaya MR
,
Wohlschlegel J,
Loo JA,
Rodriguez JA,
Clarke SG
(2025) J Biol Chem , 301 , 110735 - 110735
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): T32GM136614 (United States)
- National Science Foundation (NSF, United States): MCB-1714569 (United States)
- National Science Foundation (NSF, United States): DMR-1548924 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R35GM128867 (United States)
- National Institutes of Health/National Center for Research Resources (NIH/NCRR): S10RR028893 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R35GM145286 (United States)
- Department of Energy (DOE, United States): DE-FC02-02ER63421 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): T32GM145388 (United States)
