EMD-70501

Single-particle
2.46 Å
EMD-70501
3D View Gallery
Deposition: 05/05/2025
Map released: 27/05/2026
Last modified: 27/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70501
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9ohn summary report (pdf.gz) Map and 9ohn FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of human p97/VCP bound to inhibitor GND-135

EMD-70501

Single-particle
2.46 Å
EMD-70501
3D View Gallery
Deposition: 05/05/2025
Map released: 27/05/2026
Last modified: 27/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: human p97/VCP
Fitted models: 9ohn

Deposition Authors: Crawford J, Munuganti R, Leung C, Singh K, Gates E, Zhu X, Bally M, Dos Santos N, Sharifiaghdam M, Nosrati Z, Axerio-Cilies P, Berezuk A, Cholak S, Cameron D, Subramaniam S

Cryo-EM-guided subtractive optimization of a novel VCP/p97 inhibitor
Crawford J, Munuganti R, Leung C, Singh K, Gates E, Zhu X, Bally M, Dos Santos N, Sharifiaghdam M, Nosrati Z, Axerio-Cilies P, Berezuk A, Cholak S, Cameron D, Subramaniam S
To Be Published
Grant Support: