EMD-70487

Single-particle
2.87 Å
EMD-70487
3D View Gallery
Deposition: 04/05/2025
Map released: 11/03/2026
Last modified: 11/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70487

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9ohd summary report (pdf.gz) Map-9ohd FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

CryoEM structure of Toxin B (TcdB) from clostridioides difficile complexed with methyl cholate

EMD-70487

Single-particle
2.87 Å
EMD-70487
3D View Gallery
Deposition: 04/05/2025
Map released: 11/03/2026
Last modified: 11/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Clostridioides difficile
Sample: Clostridioides difficile Toxin B (TcdB) complexed with the synthetic bile acid methyl cholate
Fitted models: 9ohd

Deposition Authors: Miletic S , Li Z, Melnyk RA
Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin.
Miletic S , Icho S, Li Z, Tam J, Rose EC, Perkins CE , Nakhi A, Yang X, Hang HC , Rubinstein JL , Dosa PI , Theriot CM , Melnyk RA
(2025) Nat Microbiol , 10 , 3215 - 3228
PUBMED: 41254394
DOI: doi:10.1038/s41564-025-02179-1
ISSN: 2058-5276