EMD-70459
Cryo-EM structure of human full-length XPO1 conjugated with selinexor
EMD-70459
Single-particle3.37 Å
Deposition: 30/04/2025Map released: 26/11/2025
Last modified: 22/07/2026
Sample Organism:
Homo sapiens
Sample: Human wildtype full-length exportin-1 (XPO1) covalently bound to selinexor
Fitted models: 9oga
Deposition Authors: Wing CE
,
Fung HYJ ,
Chook YM
Sample: Human wildtype full-length exportin-1 (XPO1) covalently bound to selinexor
Fitted models: 9oga
Deposition Authors: Wing CE
,
Fung HYJ ,
Chook YM
SINE compounds activate exportin 1 degradation through an allosteric mechanism.
Wing CE ,
Fung HYJ ,
Kwanten B ,
Cagatay T ,
Niesman AB ,
Jacquemyn M ,
Gharghabi M ,
Permentier B ,
Shakya B,
Nandi R,
Ready JM,
Kashyap T,
Shacham S,
Landesman Y,
Lapalombella R ,
Daelemans D ,
Chook YM
(2025) Nat Chem Biol , 21 , 2002 - 2013
,
Fung HYJ ,
Kwanten B ,
Cagatay T ,
Niesman AB ,
Jacquemyn M ,
Gharghabi M ,
Permentier B ,
Shakya B,
Nandi R,
Ready JM,
Kashyap T,
Shacham S,
Landesman Y,
Lapalombella R ,
Daelemans D ,
Chook YM
(2025) Nat Chem Biol , 21 , 2002 - 2013
Grant Support:
- Cancer Prevention and Research Institute of Texas (CPRIT): RP220582 (United States)
- Cancer Prevention and Research Institute of Texas (CPRIT): RP180410 (United States)
- Cancer Prevention and Research Institute of Texas (CPRIT): RP150053 (United States)
- Cancer Prevention and Research Institute of Texas (CPRIT): RP170170 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R35GM144137 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): T32GM131963 (United States)
- Welch Foundation: I-1532 (United States)