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EMD-7039
3.3 angstrom phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.
EMD-7039
Single-particle3.3 Å
Deposition: 22/09/2017Map released: 21/02/2018
Last modified: 23/10/2024
Sample Organism:
Homo sapiens,
synthetic construct,
Lama glama
Sample: Complex of a full-length, active-state glucagon-like peptide-1 receptor with exendin-P5 ligand, heterotrimeric Gs protein and nanobody 35.
Fitted models: 6b3j
Deposition Authors: Liang YL, Khoshouei M
Sample: Complex of a full-length, active-state glucagon-like peptide-1 receptor with exendin-P5 ligand, heterotrimeric Gs protein and nanobody 35.
Fitted models: 6b3j
Deposition Authors: Liang YL, Khoshouei M
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.
Liang YL,
Khoshouei M,
Glukhova A 
,
Furness SGB ,
Zhao P,
Clydesdale L,
Koole C,
Truong TT,
Thal DM ,
Lei S,
Radjainia M,
Danev R,
Baumeister W,
Wang MW,
Miller LJ,
Christopoulos A ,
Sexton PM ,
Wootten D
(2018) Nature , 555 , 121 - 125
,
Furness SGB ,
Zhao P,
Clydesdale L,
Koole C,
Truong TT,
Thal DM ,
Lei S,
Radjainia M,
Danev R,
Baumeister W,
Wang MW,
Miller LJ,
Christopoulos A ,
Sexton PM ,
Wootten D
(2018) Nature , 555 , 121 - 125
Grant Support:
- National Health and Medical Research Council (NHMRC, Australia): 1061044 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 1065410 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 1126857 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 1055134 (Australia)