EMD-70159

Single-particle
3.0 Å
EMD-70159
3D View Gallery
Deposition: 11/04/2025
Map released: 21/01/2026
Last modified: 25/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70159

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9o65 summary report (pdf.gz) Map-9o65 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of SHOC2-KRAS-PP1CA (SKP) complex

EMD-70159

Single-particle
3.0 Å
EMD-70159
3D View Gallery
Deposition: 11/04/2025
Map released: 21/01/2026
Last modified: 25/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Ternary complex of SHOC2, KRAS, and PP1CA
Fitted models: 9o65

Deposition Authors: Finci LI, Bonsor DA , Simanshu DK
Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors.
Bonsor DA , Finci LI, Potter JR , Young LC, Wall VE, Goldstein de Salazar R, Geis KR, Stephens T, Finney J, Nissley DV , McCormick F , Simanshu DK
(2026) Nat Commun , 17 , 1614 - 1614
PUBMED: 41519889
DOI: doi:10.1038/s41467-026-68319-1
ISSN: 2041-1723