EMD-70123

Single-particle
3.5 Å
EMD-70123
3D View Gallery
Deposition: 09/04/2025
Map released: 25/06/2025
Last modified: 25/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70123

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9o54 summary report (pdf.gz) Map-9o54 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

ADAM17 Prodomain-Metalloproteinase Domains bound to MEDI3622 Fab

EMD-70123

Single-particle
3.5 Å
EMD-70123
3D View Gallery
Deposition: 09/04/2025
Map released: 25/06/2025
Last modified: 25/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human ADAM17 Pro-Metalloprotease Bound to MEDI3622 Fab
Fitted models: 9o54

Deposition Authors: Slone CE, Maciag JJ
Structural insights into the activation and inhibition of the ADAM17-iRhom2 complex.
Maciag JJ , Slone CE, Alnajjar HF, Rich MF, Guion B, Ifergan I , Blobel CP , Seegar TCM
(2025) PNAS , 122 , e2500732122 - e2500732122
PUBMED: 40512800
DOI: doi:10.1073/pnas.2500732122
ISSN: 1091-6490
ASTM: PNASA6