EMD-70071
CryoEM structure of mu-opioid receptor - Gi protein complex bound to fluornitrazene (FNZ)
EMD-70071
Single-particle2.3 Å
Deposition: 05/04/2025Map released: 01/04/2026
Last modified: 13/05/2026
Sample Organism:
Homo sapiens,
Mus musculus
Sample: MOR-Gi heterotrimer complex
Fitted models: 9o36
Deposition Authors: Robertson MJ
,
Skiniotis G
Sample: MOR-Gi heterotrimer complex
Fitted models: 9o36
Deposition Authors: Robertson MJ
,
Skiniotis G
A μ-opioid receptor superagonist analgesic with minimal adverse effects.
Gomez JL,
Ventriglia EN,
Frangos ZJ ,
Sulima A,
Robertson MJ ,
Sacco MD,
Budinich RC,
Giosan IM,
Xie T ,
Solis O ,
Tischer AE ,
Bossert JM,
Caldwell KE,
Bonbrest H,
Essmann A ,
Garcon-Poca ZM ,
Choi S ,
Noya MR,
Limiac F ,
Arce A,
Glatfelter GC,
Robinson M,
Chen L,
Mullarkey AA,
Brademan DR,
Enten G ,
Dunne W ,
Quiroz C,
Schoenborn I ,
Lee CB,
Rais R,
Holt DP,
Dannals RF,
Shi L ,
Huttenhain R,
Ferre S ,
Kiyatkin E,
Bonaventura J ,
Shaham Y ,
Zachariou V,
Baumann MH,
Skiniotis G ,
Rice KC ,
Michaelides M
(2026) Nature , 652 , 1393 - 1404
,
Sulima A,
Robertson MJ ,
Sacco MD,
Budinich RC,
Giosan IM,
Xie T ,
Solis O ,
Tischer AE ,
Bossert JM,
Caldwell KE,
Bonbrest H,
Essmann A ,
Garcon-Poca ZM ,
Choi S ,
Noya MR,
Limiac F ,
Arce A,
Glatfelter GC,
Robinson M,
Chen L,
Mullarkey AA,
Brademan DR,
Enten G ,
Dunne W ,
Quiroz C,
Schoenborn I ,
Lee CB,
Rais R,
Holt DP,
Dannals RF,
Shi L ,
Huttenhain R,
Ferre S ,
Kiyatkin E,
Bonaventura J ,
Shaham Y ,
Zachariou V,
Baumann MH,
Skiniotis G ,
Rice KC ,
Michaelides M
(2026) Nature , 652 , 1393 - 1404
Grant Support: