EMD-70071

Single-particle
2.3 Å
EMD-70071
3D View Gallery
Deposition: 05/04/2025
Map released: 01/04/2026
Last modified: 01/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70071
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9o36 summary report (pdf.gz) Map and 9o36 FULL report (pdf.gz)
EMICSS annotations (xml)

CryoEM structure of mu-opioid receptor - Gi protein complex bound to fluornitrazene (FNZ)

EMD-70071

Single-particle
2.3 Å
EMD-70071
3D View Gallery
Deposition: 05/04/2025
Map released: 01/04/2026
Last modified: 01/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: MOR-Gi heterotrimer complex
Fitted models: 9o36

Deposition Authors: Robertson MJ, Skiniotis G
A mu-opioid receptor superagonist analgesic with minimal adverse effects
Gomez JL, Ventriglia EN, Frangos ZJ, Sulima A, Robertson MJ, Sacco M, Budinich R, Giosan I, Solis O, Tischer AE, Bossert JM, Caldwell KE, Bonbrest H, Essmann A, Garcon-Poca MZ, Choi S, Noya MR, Glatfelter G, Robinson M, Mullarkey AA, Brademan DR, Enten G, Dunne W, Schoenborn I, Paule J, Rais R, Holt DP, Dannals RF, Tanda G, Newman AH, Shi L, Huttenhain R, Ferre S, Kiyatkin E, Bonaventura J, Shaham Y, Zachariou V, Baumann MH, Skiniotis G, Rice KC, Michaelides M
(2026) Nature
DOI: doi:10.1038/s41586-026-10299-9
ISSN: 1476-4687
ASTM: NATUAS
Grant Support: