EMD-69467

Single-particle
2.39 Å
EMD-69467
3D View Gallery
Deposition: 02/03/2026
Map released: 03/06/2026
Last modified: 24/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-69467

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-24ew summary report (pdf.gz) Map-24ew FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

SARS-CoV-2 polymerase with incorporated and pre-incorporated AT-9052-Sp

EMD-69467

Single-particle
2.39 Å
EMD-69467
3D View Gallery
Deposition: 02/03/2026
Map released: 03/06/2026
Last modified: 24/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Severe acute respiratory syndrome coronavirus 2, synthetic construct
Sample: ternary RNA-RTC-AT-9052-SP complex
Fitted models: 24ew

Deposition Authors: Zhu YX, Shi H, Wang MF
Consecutive catalytic steps of viral RNA polymerase and exonuclease suggest a way to overcome intrinsic nucleotide analogue resistance.
Shannon A, Fattorini V, Sartre C, Chazot A, Moussa A, Sommadossi JP, Zhu Y, Wang M, Shi H, Ferron F, Alvarez K, Canard B
(2026) PNAS , 123 , e2605725123 - e2605725123
PUBMED: 42263136
DOI: doi:10.1073/pnas.2605725123
ISSN: 1091-6490
ASTM: PNASA6