EMD-68650

Single-particle
3.2 Å
EMD-68650
3D View Gallery
Deposition: 22/01/2026
Map released: 21/10/2026
Last modified: 21/10/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-68650

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-22ta summary report (pdf.gz) Map-22ta FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

5HT2AR-miniGq heterotrimer in complex with a novel agonist IHCH-8152

EMD-68650

Single-particle
3.2 Å
EMD-68650
3D View Gallery
Deposition: 22/01/2026
Map released: 21/10/2026
Last modified: 21/10/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: 5-HT2A receptor bound to IHCH-8152 in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM)
Fitted models: 22ta

Deposition Authors: Tang L, Cao M, Li H, Meng B, Liu Z, Cheng J , Wang S

Mechanisms Underlying Sustained Antidepressant Effects of Psychedelics Inspire Microdosing Strategies
He L, Tang L, Cao D, Duan W, Yu J, Zhang P, Li H, Wang Y, Meng B, Wang H, Zhou Y, Li W, Li X, Liu Z, Zhang L, Li L, Cheng J , Wang S
To Be Published