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EMD-67603

Single-particle
2.95 Å
EMD-67603
3D View Gallery
Deposition: 09/12/2025
Map released: 01/04/2026
Last modified: 06/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-67603
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 21dx summary report (pdf.gz) Map and 21dx FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the human P2X3 receptor in the ATP-bound, desensitized state

EMD-67603

Single-particle
2.95 Å
EMD-67603
3D View Gallery
Deposition: 09/12/2025
Map released: 01/04/2026
Last modified: 06/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: human P2X3 trimer
Fitted models: 21dx

Deposition Authors: Hattori M , Zhao Z
Structure of the human P2X3 receptor reveals the basis for subtype-selective inhibition by sivopixant.
Zhao Z, Wang DP, Zhang X, Gao Y, Xu H, Teng X, Shen C, Chen J, Zhang J, Guo CR, Hattori M
(2026) PLoS Biol , 24 , e3003777 - e3003777
PUBMED: 42018567
DOI: doi:10.1371/journal.pbio.3003777
ISSN: 1545-7885
Grant Support:
  • National Natural Science Foundation of China (NSFC): (China)
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