EMD-67430

Single-particle
2.4 Å
EMD-67430
3D View Gallery
Deposition: 03/12/2025
Map released: 03/06/2026
Last modified: 03/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-67430
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 20zh summary report (pdf.gz) Map and 20zh FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the human neurotensin receptor 1 (hNTSR1)-Gi1 complex in the GTP-bound, AHD-open C state 2, plunge-frozen 0-5 seconds after GTP addition

EMD-67430

Single-particle
2.4 Å
EMD-67430
3D View Gallery
Deposition: 03/12/2025
Map released: 03/06/2026
Last modified: 03/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus, synthetic construct
Sample: JMV449-bound human neurotensin receptor 1 (hNTSR1)-Gi1 complex in the GTP-bound, AHD-open C state 2 with scFv16, plunge-frozen 0-5 seconds after GTP addition
Fitted models: 20zh

Deposition Authors: Kobayashi K, Matsui TE, Fukuda M, Kawakami K, Yamashita K, Kato HE, Kato HE
The dynamic basis of G-protein recognition and activation by a GPCR.
Kobayashi K, Kawakami K, Matsui TE, Yokoi S, Fukuda M, Narita TJ, Arai H, Tambo M, Sumikama T, Tatsumi M, Yamashita K, Koyanagi J, Kugawa M, Ikeda H, Sumino A, Mitsutake A, Kobilka BK, Inoue A, Kato HE
(2026) Nature , 652 , 812 - 821
PUBMED: 41813902
DOI: doi:10.1038/s41586-026-10228-w
ISSN: 1476-4687
ASTM: NATUAS