EMD-67328

Single-particle
2.86 Å
EMD-67328
3D View Gallery
Deposition: 27/11/2025
Map released: 23/09/2026
Last modified: 23/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-67328

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9xw8 summary report (pdf.gz) Map-9xw8 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of PI3Kalpha E542K mutation in complex with STX-478

EMD-67328

Single-particle
2.86 Å
EMD-67328
3D View Gallery
Deposition: 27/11/2025
Map released: 23/09/2026
Last modified: 23/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human PI3Kalpha E542K in complex with STX-478
Fitted models: 9xw8

Deposition Authors: Liu X, Chen Y, Li G, Chen A, Zhou Q, Wang M-W
Molecular architecture responsible for specific inhibition of oncogenic PI3K alpha mutants by RLY-2608 and STX-478
Liu X, Chen Y, Li G, Chen A, Zhou Q, Wang MW
(2026) Acta Pharm Sin B
DOI: doi:10.1016/j.apsb.2026.07.003
ISSN: 2211-3843