EMD-66849

Helical reconstruction
2.86 Å
EMD-66849
3D View Gallery
Deposition: 30/10/2025
Map released: 04/11/2026
Last modified: 04/11/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-66849

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9xgj summary report (pdf.gz) Map-9xgj FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Second-generation 2N4R human tau filaments seeded by Alzheimer's disease tau in the presence of heparan sulfate

EMD-66849

Helical reconstruction
2.86 Å
EMD-66849
3D View Gallery
Deposition: 30/10/2025
Map released: 04/11/2026
Last modified: 04/11/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Tau
Fitted models: 9xgj

Deposition Authors: Zeng W, Sun S, Shi Y, He Z

Golgi-derived glycosaminoglycans are involved in pathological tau seeds formation as the cofactor in Alzheimer's disease and related tauopathies
Zeng W, Sun S, Li Q, Sun Z, Hu Y, Duan J, Zhao B, Zheng H, EunRan S, Vivianna MVD, Xu P, Yu B, Qiu H, Yuan W, Shi Y, He Z
To Be Published