EMD-66192

Single-particle
3.43 Å
EMD-66192
3D View Gallery
Deposition: 12/09/2025
Map released: 10/06/2026
Last modified: 05/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-66192

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9ws4 summary report (pdf.gz) Map-9ws4 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cyro-EM structure of the ACT-451840-bound PfMDR1

EMD-66192

Single-particle
3.43 Å
EMD-66192
3D View Gallery
Deposition: 12/09/2025
Map released: 10/06/2026
Last modified: 05/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Plasmodium falciparum 3D7
Sample: Genes encoding full-length PfMDR1 were synthesized and subcloned into a modified pCAG vector with an N-terminal twin-strep tag.
Fitted models: 9ws4

Deposition Authors: Zhao Z, Li J , Wang X , Liu X, Wang N , Xu H, Quan C, Wang X , Kato N, Deng D , Jing X
Structural and mechanistic insights into the inhibition of Plasmodium falciparum MDR1.
Zhao Z, Li J , Wang X , Liu X, Wang N , Xu H, Quan C, Gao Y, Zhang J, Wang X , Guo L, Kato N, Deng D , Jiang X
(2026) Nat Commun , 17
PUBMED: 42203772
DOI: doi:10.1038/s41467-026-73692-y
ISSN: 2041-1723