EMD-66192

Single-particle
3.43 Å
EMD-66192
3D View Gallery
Deposition: 12/09/2025
Map released: 10/06/2026
Last modified: 10/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-66192
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9ws4 summary report (pdf.gz) Map and 9ws4 FULL report (pdf.gz)
EMICSS annotations (xml)

Cyro-EM structure of the ACT-451840-bound PfMDR1

EMD-66192

Single-particle
3.43 Å
EMD-66192
3D View Gallery
Deposition: 12/09/2025
Map released: 10/06/2026
Last modified: 10/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Plasmodium falciparum 3D7
Sample: Genes encoding full-length PfMDR1 were synthesized and subcloned into a modified pCAG vector with an N-terminal twin-strep tag.
Fitted models: 9ws4

Deposition Authors: Zhao Z, Li J, Wang X, Liu X, Wang N, Xu H, Quan C, Wang X, Kato N, Deng D, Jing X
Structural and mechanistic insights into the inhibition of Plasmodium falciparum MDR1.
Zhao Z, Li J, Wang X, Liu X, Wang N, Xu H, Quan C, Gao Y, Zhang J, Wang X, Guo L, Kato N, Deng D, Jiang X
(2026) Nat Commun
PUBMED: 42203772
DOI: doi:10.1038/s41467-026-73692-y
ISSN: 2041-1723