EMD-66116

Single-particle
3.13 Å
EMD-66116
3D View Gallery
Deposition: 04/09/2025
Map released: 09/09/2026
Last modified: 09/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-66116

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9wnf summary report (pdf.gz) Map-9wnf FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

5HT2AR-miniGq heterotrimer in complex with a selective agonist IHCH-2330

EMD-66116

Single-particle
3.13 Å
EMD-66116
3D View Gallery
Deposition: 04/09/2025
Map released: 09/09/2026
Last modified: 09/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: 5-HT2A receptor bound to IHCH-2330 in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM)
Fitted models: 9wnf

Deposition Authors: Tang L, Ji Y, Cheng J , Wang S

Mechanistic Basis for 5-HT2AR Over 5-HT2BR Activation
Tang L, Ji X, Cao D, Li H, Wang S , Cheng J
To Be Published