EMD-65367

Single-particle
3.13 Å
EMD-65367
3D View Gallery
Deposition: 13/07/2025
Map released: 27/05/2026
Last modified: 27/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-65367

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9vul summary report (pdf.gz) Map-9vul FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of the human measles virus RNA-dependent RNA polymerase bound to allosteric inhibitor ERDRP-0519

EMD-65367

Single-particle
3.13 Å
EMD-65367
3D View Gallery
Deposition: 13/07/2025
Map released: 27/05/2026
Last modified: 27/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Measles virus genotype A-vaccine, synthetic construct
Sample: Measles virus RNA-dependent RNA polymerase complex bound to allosteric inhibitor ERDRP-0519
Fitted models: 9vul

Deposition Authors: Du T, Wang J, Wu S, Ru H
Structural insights into measles virus RNA synthesis regulation and pan-paramyxoviral polymerase inhibition by ERDRP-0519.
Du T, Wang J, Yang C, Xue R, Chen Y, Jie K, Zhang X, Zhang L, Song G, Zhang Q, Wu S, Ru H
(2026) PNAS , 123 , e2522978123 - e2522978123
PUBMED: 41941628
DOI: doi:10.1073/pnas.2522978123
ISSN: 1091-6490
ASTM: PNASA6