EMD-65193

Single-particle
2.4 Å
EMD-65193
3D View Gallery
Deposition: 28/06/2025
Map released: 18/03/2026
Last modified: 15/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-65193
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9vmo summary report (pdf.gz) Map and 9vmo FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the ITA-OXGR1-Gq complex

EMD-65193

Single-particle
2.4 Å
EMD-65193
3D View Gallery
Deposition: 28/06/2025
Map released: 18/03/2026
Last modified: 15/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: Cryo-EM structure of the ITA-OXGR1-Gq complex
Fitted models: 9vmo

Deposition Authors: Tang XJ, Sun JP , Guo LL, Li J, Deng ZL, Xiao WQ, Zhu Y, Zhu KK
Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema.
Xiao W, Zhu Y, Tang X, Zhu K, Zhang W, Chen M, Cai K, Xu S, Wu Z, Wang M, Liu J, Long L, Tan Z, Wu A, Zhou S, Zhao Z, Tang Y, Huang Y, Wang B, Liu F, Wang Q, Yang F, Jian D, Shi W, Xie H, Chen X, Guo L, Deng Z, Sun J, Li J
(2026) Cell , 189 , 1990 - 2006.e30
PUBMED: 41791372
DOI: doi:10.1016/j.cell.2026.01.036
ISSN: 1097-4172