EMD-64402

Single-particle
2.8 Å
EMD-64402
3D View Gallery
Deposition: 29/04/2025
Map released: 29/04/2026
Last modified: 29/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-64402

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9upu summary report (pdf.gz) Map-9upu FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM strucutre of CXCR4 complexed with agonist SDV1a

EMD-64402

Single-particle
2.8 Å
EMD-64402
3D View Gallery
Deposition: 29/04/2025
Map released: 29/04/2026
Last modified: 29/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Oplophorus gracilirostris
Sample: SDV1a-CXCR4-DNGi-scFv16
Fitted models: 9upu

Deposition Authors: Jiao HZ, Sang XH, Huang ZW, Hu HL
The cryo-EM-delineated mechanism underlying mimicry of CXCR4 agonism enables widespread stem cell neuroprotection in a mouse model of ALS.
Sang X, Jiao H, Meng Q, Fang X, Sundaram KS, Zhou J, Xu Y, Alvarado AIW, Nuryyev RL, Ourenik J, Ourednik V, Huang IS, Liu X, Mei Y, Qian T, Ciechanover A, Pizzo DP, Lane MA, Zholudeva LV, An J, Snyder EY, Hu H, Huang Z
(2025) bioRxiv
PUBMED: 40672153
DOI: doi:10.1101/2025.07.08.663251
ISSN: 2692-8205
Grant Support: