EMD-64093
Structure of the SFTSV Gn head protein in complex with Nb261 and Nb318
EMD-64093
Single-particle3.62 Å
Deposition: 09/04/2025Map released: 29/10/2025
Last modified: 09/09/2026
Sample Organism:
Severe fever with thrombocytopenia syndrome virus,
Vicugna pacos
Sample: Gn head protein in complex with Nb261 and Nb318
Fitted models: 9uev
Deposition Authors: Liang SJ, Lou ZY, Wu XL
Sample: Gn head protein in complex with Nb261 and Nb318
Fitted models: 9uev
Deposition Authors: Liang SJ, Lou ZY, Wu XL
A rationally designed cocktail of nanobodies elicited by heterologous vaccination confers protection against SFTSV in preclinical models.
Wu X 
,
Zhu L ,
Liang S ,
Chang Z,
Wang Y ,
Zou Q ,
Xu Z,
Zhang D,
Hu J ,
Geng S ,
Li Z,
Yu W,
Hu Z ,
Chen M ,
Cao K,
Jia B,
Wei H,
Cai R,
Long J ,
Yang X ,
Yang Q ,
Yu Z,
Shi L ,
Xu B ,
Zheng Y,
Meng S ,
Cai J,
Zhou G,
Zhu K ,
Dou Y ,
Lou Z ,
Li M ,
Wu Y ,
Wu Z
(2025) Sci Transl Med , 17 , eady9025 - eady9025
,
Zhu L ,
Liang S ,
Chang Z,
Wang Y ,
Zou Q ,
Xu Z,
Zhang D,
Hu J ,
Geng S ,
Li Z,
Yu W,
Hu Z ,
Chen M ,
Cao K,
Jia B,
Wei H,
Cai R,
Long J ,
Yang X ,
Yang Q ,
Yu Z,
Shi L ,
Xu B ,
Zheng Y,
Meng S ,
Cai J,
Zhou G,
Zhu K ,
Dou Y ,
Lou Z ,
Li M ,
Wu Y ,
Wu Z
(2025) Sci Transl Med , 17 , eady9025 - eady9025
Grant Support: