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EMD-63457

Single-particle
3.3 Å
EMD-63457
3D View Gallery
Deposition: 16/02/2025
Map released: 01/10/2025
Last modified: 01/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-63457
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9lwr summary report (pdf.gz) Map and 9lwr FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of PI3Kalpha H1047R in complex with compound UCL-TRO-1938

EMD-63457

Single-particle
3.3 Å
EMD-63457
3D View Gallery
Deposition: 16/02/2025
Map released: 01/10/2025
Last modified: 01/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human PI3Kalpha H1047R in complex with 1938
Fitted models: 9lwr

Deposition Authors: Liu X, Zhou Q
Molecular mechanisms of PI3K alpha activation by small-molecule activator 1938 and cancer-specific mutation H1047R.
Liu X, Zhou Q, Chen Y, Han W, Li J, Mai Y, Wang MW
(2025) Cell Discov , 11 , 77 - 77
PUBMED: 40968123
DOI: doi:10.1038/s41421-025-00833-w
ISSN: 2056-5968