EMD-63195
Ariadne-bound Serotonin 2A (5-HT2A) receptor-Gq complex
EMD-63195
Single-particle3.27 Å
Deposition: 17/01/2025Map released: 14/01/2026
Last modified: 01/04/2026
Sample Organism:
Homo sapiens
Sample: 5-HT2AR-bound DOI in complex with Gi heterotrimer
Fitted models: 9lla
Deposition Authors: Xu Z
,
Shao ZH
Sample: 5-HT2AR-bound DOI in complex with Gi heterotrimer
Fitted models: 9lla
Deposition Authors: Xu Z
,
Shao ZH
Psychedelics elicit their effects by 5-HT 2A receptor-mediated G i signalling.
Xu Z ,
Wang H,
Yu J ,
Deng Y,
Tian X ,
Ni R ,
Xia F,
Yang L,
Xu C ,
Zhang L ,
Luo R,
Chen P,
Zhang X,
Liu Y ,
Hou J,
Zhang M,
Chen S,
Su L,
Sun H ,
He Y,
Chen D,
Chen X,
Miao Z,
Xie J ,
Liu X,
Zhao J ,
Ke B ,
Tian X ,
Zeng L,
Zhang L ,
Tang X,
Yang S ,
Liu J ,
Wang X ,
Yan W ,
Shao Z
(2026) Nature , 651 , 829 - 837
,
Wang H,
Yu J ,
Deng Y,
Tian X ,
Ni R ,
Xia F,
Yang L,
Xu C ,
Zhang L ,
Luo R,
Chen P,
Zhang X,
Liu Y ,
Hou J,
Zhang M,
Chen S,
Su L,
Sun H ,
He Y,
Chen D,
Chen X,
Miao Z,
Xie J ,
Liu X,
Zhao J ,
Ke B ,
Tian X ,
Zeng L,
Zhang L ,
Tang X,
Yang S ,
Liu J ,
Wang X ,
Yan W ,
Shao Z
(2026) Nature , 651 , 829 - 837
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