EMD-63050

Single-particle
3.73 Å
EMD-63050
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Deposition: 08/01/2025
Map released: 13/08/2025
Last modified: 17/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-63050
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9lfl summary report (pdf.gz) Map and 9lfl FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of linker-extended biparatopic antibody BA1-GP4 in complex with TNFR2

EMD-63050

Single-particle
3.73 Å
EMD-63050
3D View Gallery
Deposition: 08/01/2025
Map released: 13/08/2025
Last modified: 17/09/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus, Homo sapiens
Sample: Linker-extended biparatopic antibody BA1-GP4 in complex with TNFR2
Fitted models: 9lfl

Deposition Authors: Otsuki T, Matsumoto S, Fujita J, Miyata T, Namba K, Kanada R, Okuno Y, Kamada H, Ohno H, Akiba H
Conversion of an agonistic anti-TNFR2 biparatopic antibody into an antagonist by insertion of peptide linkers into the hinge region.
Otsuki T, Matsumoto S, Fujita J, Miyata T, Namba K, Kanada R, Okuno Y, Kamada H, Ohno H, Akiba H
(2025) J Biol Chem , 301 , 110548 - 110548
PUBMED: 40752574
DOI: doi:10.1016/j.jbc.2025.110548
ISSN: 1083-351X
ASTM: JBCHA3