EMD-62849
Gi-bound kappa opioid receptor in complex with dynorphin and positive allosteric modulator MPAM-15
EMD-62849
Single-particle2.9 Å
Deposition: 23/12/2024Map released: 31/12/2025
Last modified: 11/03/2026
Sample Organism:
Homo sapiens,
Rattus norvegicus,
Bos taurus
Sample: Quaternary complex of kappa opioid receptor coupled to Gi heterotrimer
Fitted models: 9l60
Deposition Authors: Zhuang Y
,
Wang Y ,
Xu Y ,
Luo P ,
Xu HE
Sample: Quaternary complex of kappa opioid receptor coupled to Gi heterotrimer
Fitted models: 9l60
Deposition Authors: Zhuang Y
,
Wang Y ,
Xu Y ,
Luo P ,
Xu HE
Structure-based design of an opioid receptor modulator for enhanced morphine analgesia.
Wang Y ,
Luo P ,
Xu H,
Zhan L,
Sakamoto K ,
Li M,
Wang J ,
Huang XP ,
Zhou J ,
Liu T,
Suo Y ,
Fan W,
He X ,
Xu Y ,
Cai Y,
Wang C ,
Zhao Y,
Dai A ,
Lai Y,
Yuan Q,
Hu W ,
Wu K,
Yang D ,
Cheng X ,
Lu X ,
Krumm B,
Kenakin T ,
Zhang J ,
Roth BL ,
Gao Z ,
Xu HE ,
Zhuang Y
(2026) Sci Adv , 12 , eaea9832 - eaea9832
,
Luo P ,
Xu H,
Zhan L,
Sakamoto K ,
Li M,
Wang J ,
Huang XP ,
Zhou J ,
Liu T,
Suo Y ,
Fan W,
He X ,
Xu Y ,
Cai Y,
Wang C ,
Zhao Y,
Dai A ,
Lai Y,
Yuan Q,
Hu W ,
Wu K,
Yang D ,
Cheng X ,
Lu X ,
Krumm B,
Kenakin T ,
Zhang J ,
Roth BL ,
Gao Z ,
Xu HE ,
Zhuang Y
(2026) Sci Adv , 12 , eaea9832 - eaea9832