Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-62849

Single-particle
2.9 Å
EMD-62849
3D View Gallery
Deposition: 23/12/2024
Map released: 31/12/2025
Last modified: 31/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-62849
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9l60 summary report (pdf.gz) Map and 9l60 FULL report (pdf.gz)
EMICSS annotations (xml)

Gi-bound kappa opioid receptor in complex with dynorphin and positive allosteric modulator MPAM-15

EMD-62849

Single-particle
2.9 Å
EMD-62849
3D View Gallery
Deposition: 23/12/2024
Map released: 31/12/2025
Last modified: 31/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Rattus norvegicus, Bos taurus
Sample: Quaternary complex of kappa opioid receptor coupled to Gi heterotrimer
Fitted models: 9l60

Deposition Authors: Zhuang Y, Wang Y, Xu Y, Luo P, Xu HE

Structure-based design of an opioid receptor modulator for enhanced morphine analgesia
Wang Y, Xu Y, Xu HE, Zhuang Y
To Be Published