EMD-62577

Single-particle
2.45 Å
EMD-62577
3D View Gallery
Deposition: 03/12/2024
Map released: 16/07/2025
Last modified: 30/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-62577

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9kuf summary report (pdf.gz) Map-9kuf FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of HsClpP bound to CLPP-2068

EMD-62577

Single-particle
2.45 Å
EMD-62577
3D View Gallery
Deposition: 03/12/2024
Map released: 16/07/2025
Last modified: 30/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Complex of HsClpP with CLPP-2068
Fitted models: 9kuf

Deposition Authors: Zhao H, Yuan Q, Yin W
Harnessing the Magic Methyl Effect: Discovery of CLPP-2068 as a Novel HsClpP Activator for the Treatment of Diffuse Large B-Cell Lymphoma.
Sun M, Chen B, Teng D, Zhao H, Liao Y, Zhang C, Huang Q, Ma H, Wang C, Lin X, Yu P, Yuan Q, Yu J, Xu L, Hu X, Ye F , Diao X , Zheng M , Yin W, Zhou Y, Li J, Wang M
(2025) J Med Chem , 68 , 4287 - 4307
PUBMED: 39935096
DOI: doi:10.1021/acs.jmedchem.4c02016
ISSN: 0022-2623
ASTM: JMCMAR