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EMD-62520
Cryo-EM structure of MPXV core protease in complex with the substrate derivative I-G18
EMD-62520
Single-particle2.8 Å
Deposition: 27/11/2024Map released: 12/03/2025
Last modified: 16/07/2025
Sample Organism:
Monkeypox virus
Sample: DIMER
Fitted models: 9kr6
Deposition Authors: Lan W, You T
,
Li D,
Dong X ,
Wang H,
Xu J,
Wang W ,
Gao Y ,
Yang H
Sample: DIMER
Fitted models: 9kr6
Deposition Authors: Lan W, You T
,
Li D,
Dong X ,
Wang H,
Xu J,
Wang W ,
Gao Y ,
Yang H
Substrate recognition and cleavage mechanism of the monkeypox virus core protease.
Gao Y ,
Xie X ,
Zhang X,
Cao J,
Lan W,
You T ,
Li D,
Dong X ,
Dai W,
Xiang Y,
Hu S,
Shang W,
Wu B ,
Zhang Y ,
Xu J,
Liu X,
Wang H,
Hu W,
Zhang M,
Duan Y ,
Cui W,
Zhou H ,
Mao S,
Jia H,
Sun Z,
Jia M ,
Yin Y ,
Nguyen HC ,
Yang K,
Yang B ,
Yang X ,
Ji X ,
Xiao G ,
Wang W ,
Zhang L ,
Rao Z ,
Liu H ,
Yang H
(2025) Nature , 643 , 271 - 279
,
Xie X ,
Zhang X,
Cao J,
Lan W,
You T ,
Li D,
Dong X ,
Dai W,
Xiang Y,
Hu S,
Shang W,
Wu B ,
Zhang Y ,
Xu J,
Liu X,
Wang H,
Hu W,
Zhang M,
Duan Y ,
Cui W,
Zhou H ,
Mao S,
Jia H,
Sun Z,
Jia M ,
Yin Y ,
Nguyen HC ,
Yang K,
Yang B ,
Yang X ,
Ji X ,
Xiao G ,
Wang W ,
Zhang L ,
Rao Z ,
Liu H ,
Yang H
(2025) Nature , 643 , 271 - 279
Grant Support: