EMD-62427
Cryo-EM structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2 and anti-CD25 Fab S417
EMD-62427
Single-particle2.97 Å
Deposition: 15/11/2024Map released: 19/11/2025
Last modified: 18/02/2026
Sample Organism:
Homo sapiens,
synthetic construct,
sythetic construct
Sample: Heterotrimeric interleukin-2 receptor in complex with interleukin-2 and Fab S417
Fitted models: 9kmc
Deposition Authors: Katsura K
,
Matsumoto T,
Shirouzu M ,
Shirouzu M
Sample: Heterotrimeric interleukin-2 receptor in complex with interleukin-2 and Fab S417
Fitted models: 9kmc
Deposition Authors: Katsura K
,
Matsumoto T,
Shirouzu M ,
Shirouzu M
CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting.
Itoh-Nakadai A,
Liang M,
Shindo M,
Bibi C,
Tomizawa-Murasawa M,
Fujiki S,
Kaneko A,
Kanamaru E ,
Hashimoto M,
Kajita H,
Ando Y ,
Kojima M ,
Moody J ,
Iwasaki M ,
Takagi S ,
Nakagawa R,
Agrawal S,
Amitani-Iijima H,
Sato K,
Sorimachi Y,
Suzuki N,
Fukami T,
Hanada K,
Morita S,
Katsura K ,
Matsumoto T,
Kobayashi M,
Kato M,
Negishi Y,
Shirouzu M ,
Najima Y ,
Takubo K ,
Hon CC,
Uchida N ,
Taniguchi S,
Momozawa Y,
Carninci P ,
Shultz LD,
Saito Y,
de Hoon M ,
Shin JW ,
Ishikawa F
(2026) Nat Commun , 17 , 101 - 101
,
Hashimoto M,
Kajita H,
Ando Y ,
Kojima M ,
Moody J ,
Iwasaki M ,
Takagi S ,
Nakagawa R,
Agrawal S,
Amitani-Iijima H,
Sato K,
Sorimachi Y,
Suzuki N,
Fukami T,
Hanada K,
Morita S,
Katsura K ,
Matsumoto T,
Kobayashi M,
Kato M,
Negishi Y,
Shirouzu M ,
Najima Y ,
Takubo K ,
Hon CC,
Uchida N ,
Taniguchi S,
Momozawa Y,
Carninci P ,
Shultz LD,
Saito Y,
de Hoon M ,
Shin JW ,
Ishikawa F
(2026) Nat Commun , 17 , 101 - 101
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