EMD-62267

Single-particle
2.44 Å
EMD-62267
3D View Gallery
Deposition: 03/11/2024
Map released: 12/11/2025
Last modified: 10/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-62267

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9kda summary report (pdf.gz) Map-9kda FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of lipid-mediated dimer of human norepinephrine transporter NET in the presence of the antidepressant vilazodone in an inward-open state at resolution of 2.44 angstrom.

EMD-62267

Single-particle
2.44 Å
EMD-62267
3D View Gallery
Deposition: 03/11/2024
Map released: 12/11/2025
Last modified: 10/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Cryo-EM structure of lipid-mediated dimer of human norepinephrine transporter NET in the presence of the antidepressant vilazodone in an inward-open state at resolution of 2.44 angstrom.
Fitted models: 9kda

Deposition Authors: Zhang H, Xu EH, Jiang Y
Unveiling conformation-selective regulation of the norepinephrine transporter.
Zhang H, Zhang T, Wang D, Dai A, Mao J, Chen Q, Du T, Lu X, Hao Y, Zhang C, Yin YL, Hu W, Pan B, Jin S, Jiang M, Si Y, Yuan Q, Wang MW, Zheng M, Wang Z, Yang D , Xu HE, Jiang Y
(2025) Cell , 188 , 6861
PUBMED: 41138730
DOI: doi:10.1016/j.cell.2025.10.002
ISSN: 1097-4172