Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!
EMD-61294
Cryo-EM structure of MPXV protease in complex with compound A4
EMD-61294
Single-particle2.93 Å
Deposition: 25/08/2024Map released: 12/03/2025
Last modified: 16/07/2025
Sample Organism:
Monkeypox virus,
synthetic construct
Sample: Protease Dimer
Fitted models: 9jan
Deposition Authors: Gao Y
,
Xie X ,
Lan W,
Wang W ,
Yang H
Sample: Protease Dimer
Fitted models: 9jan
Deposition Authors: Gao Y
,
Xie X ,
Lan W,
Wang W ,
Yang H
Substrate recognition and cleavage mechanism of the monkeypox virus core protease.
Gao Y ,
Xie X ,
Zhang X,
Cao J,
Lan W,
You T ,
Li D,
Dong X ,
Dai W,
Xiang Y,
Hu S,
Shang W,
Wu B ,
Zhang Y ,
Xu J,
Liu X,
Wang H,
Hu W,
Zhang M,
Duan Y ,
Cui W,
Zhou H ,
Mao S,
Jia H,
Sun Z,
Jia M ,
Yin Y ,
Nguyen HC ,
Yang K,
Yang B ,
Yang X ,
Ji X ,
Xiao G ,
Wang W ,
Zhang L ,
Rao Z ,
Liu H ,
Yang H
(2025) Nature , 643 , 271 - 279
,
Xie X ,
Zhang X,
Cao J,
Lan W,
You T ,
Li D,
Dong X ,
Dai W,
Xiang Y,
Hu S,
Shang W,
Wu B ,
Zhang Y ,
Xu J,
Liu X,
Wang H,
Hu W,
Zhang M,
Duan Y ,
Cui W,
Zhou H ,
Mao S,
Jia H,
Sun Z,
Jia M ,
Yin Y ,
Nguyen HC ,
Yang K,
Yang B ,
Yang X ,
Ji X ,
Xiao G ,
Wang W ,
Zhang L ,
Rao Z ,
Liu H ,
Yang H
(2025) Nature , 643 , 271 - 279
Grant Support: