EMD-61249

Single-particle
3.36 Å
EMD-61249
3D View Gallery
Deposition: 21/08/2024
Map released: 02/04/2025
Last modified: 22/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-61249

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9j8z summary report (pdf.gz) Map-9j8z FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of human HCAR1-Gi complex without ligand (apo state)

EMD-61249

Single-particle
3.36 Å
EMD-61249
3D View Gallery
Deposition: 21/08/2024
Map released: 02/04/2025
Last modified: 22/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Cryo-EM structure of human HCAR1-Gi complex without ligand (apo state)
Fitted models: 9j8z

Deposition Authors: Xin P, Fang Y
Structures of G-protein coupled receptor HCAR1 in complex with Gi1 protein reveal the mechanistic basis for ligand recognition and agonist selectivity.
Pan X, Ye F, Ning P, Yu Y, Zhang Z, Wang J, Chen G, Wu Z, Qiu C, Li J, Chen B, Zhu L, Qian C, Gong K, Du Y
(2025) PLoS Biol , 23 , e3003126 - e3003126
PUBMED: 40233099
DOI: doi:10.1371/journal.pbio.3003126
ISSN: 1545-7885