EMD-61131

Single-particle
3.33 Å
EMD-61131
3D View Gallery
Deposition: 09/08/2024
Map released: 21/01/2026
Last modified: 21/01/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-61131

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9j4c summary report (pdf.gz) Map-9j4c FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of aPlexinA1-19-43 Fab in complex with PlexinA1 dimer

EMD-61131

Single-particle
3.33 Å
EMD-61131
3D View Gallery
Deposition: 09/08/2024
Map released: 21/01/2026
Last modified: 21/01/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus, Homo sapiens
Sample: Dimer complex of Human Plexin-A1 27-710 with aPlexinA1-19-43 Fab binding
Fitted models: 9j4c

Deposition Authors: Tian H , Fung CP
A bispecific antibody designed to act as a NRP2/PLXNA1 agonist mimics anticancer activity of SEMA3F.
Tian H , Fung CP , Burman L, Chong YE , Liu C, Geng Y, Yang L, Chow MW, Zhang Y, Ho KWH, Zhu G, Wu Z, Yang XL, Xu Z, Nangle LA
(2025) J Biol Chem , 302 , 111056 - 111056
PUBMED: 41391772
DOI: doi:10.1016/j.jbc.2025.111056
ISSN: 1083-351X
ASTM: JBCHA3
Grant Support: