EMD-60703

Single-particle
2.88 Å
EMD-60703
3D View Gallery
Deposition: 06/07/2024
Map released: 22/01/2025
Last modified: 22/01/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-60703

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9ind summary report (pdf.gz) Map-9ind FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Integrin alpha-v beta-8 in complex with the Fab of 130H2

EMD-60703

Single-particle
2.88 Å
EMD-60703
3D View Gallery
Deposition: 06/07/2024
Map released: 22/01/2025
Last modified: 22/01/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus, Homo sapiens, Homo
Sample: Integrin alpha-v beta-8 complexed with antibody Fab fragment of 130H2
Fitted models: 9ind

Deposition Authors: Sun H, Zheng Q , Gui X, Zheng Q , Li S
Specifically blocking alpha v beta 8-mediated TGF-beta signaling to reverse immunosuppression by modulating macrophage polarization.
Guo C, Sun H, Du Y, Dai X, Pang Y, Han Z, Xiong X, Li S, Zhang J, Zheng Q , Gui X
(2025) J Exp Clin Cancer Res , 44 , 1 - 1
PUBMED: 39743547
DOI: doi:10.1186/s13046-024-03250-1
ISSN: 1756-9966
Grant Support: