EMD-60550
Complex I form respirasome closed state bound by proguanil (SC-ProgC)
EMD-60550
Composite mapSingle-particle
3.14 Å
Deposition: 15/06/2024Map released: 19/11/2025
Last modified: 19/11/2025
Sample Organism:
Sus scrofa
Sample: Respirasome closed state inhibited by proguanil
Fitted models: 8zxz
Deposition Authors: Teng F
,
He ZX,
Hu YQ,
Xu CY,
Guo RY,
Zhou L
Sample: Respirasome closed state inhibited by proguanil
Fitted models: 8zxz
Deposition Authors: Teng F
,
He ZX,
Hu YQ,
Xu CY,
Guo RY,
Zhou L
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
He Z ,
Teng F ,
Yang Y ,
Guo R,
Wu M ,
Han F ,
Tian H ,
Wang J,
Hu Y ,
Jiang Y,
Zhang L,
Xu C,
Yang F ,
Zhou J ,
Zhang S ,
Letts JA ,
Zhou R ,
Zhou L
(2025) Nat Struct Mol Biol
,
Teng F ,
Yang Y ,
Guo R,
Wu M ,
Han F ,
Tian H ,
Wang J,
Hu Y ,
Jiang Y,
Zhang L,
Xu C,
Yang F ,
Zhou J ,
Zhang S ,
Letts JA ,
Zhou R ,
Zhou L
(2025) Nat Struct Mol Biol
Grant Support:
- Other government: ZJU100 Young Professor (China)