EMD-60418

Composite map
Single-particle
3.09 Å
EMD-60418
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Deposition: 05/06/2024
Map released: 19/11/2025
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-60418
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8zsk summary report (pdf.gz) Map and 8zsk FULL report (pdf.gz)
EMICSS annotations (xml)

Complex I from respirasome closed state 1 bound by metformin and CoQ10, alternative orientation (SC-MetC1-ii)

EMD-60418

Composite map
Single-particle
3.09 Å
EMD-60418
3D View Gallery
Deposition: 05/06/2024
Map released: 19/11/2025
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Sus scrofa
Sample: respirasome closed state 1 bound by metformin and CoQ(alternative orientation),comformation B
Fitted models: 8zsk

Deposition Authors: Teng F, He ZX, Hu YQ, Xu CY, Guo RY, Zhou L
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
He Z, Teng F, Yang Y, Guo R, Wu M, Han F, Tian H, Wang J, Hu Y, Jiang Y, Zhang L, Xu C, Yang F, Zhou J, Zhang S, Letts JA, Zhou R, Zhou L
(2026) Nat Struct Mol Biol , 33 , 100 - 111
PUBMED: 41214295
DOI: doi:10.1038/s41594-025-01710-6
ISSN: 1545-9985