Electron Microscopy Data Bank

EMD-60367

Single-particle
2.88 Å

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Deposition: 31/05/2024
Map released: 19/11/2025
Last modified: 04/02/2026

Overview 3D View Sample Experiment Validation Additional data Links

EMD-60367

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Cryo-EM map of respirasome closed state 1 bound by metformin and CoQ (SC-MetC1-ii)

EMD-60367

Single-particle
2.88 Å
EMD-60367

3D View Gallery

Deposition: 31/05/2024
Map released: 19/11/2025
Last modified: 04/02/2026

Overview 3D View Sample Experiment Validation Additional data Links

Sample Organism: Sus scrofa
Sample: Respirasome closed state 1 bound by metformin and CoQ(alternative orientation), comformation A

Deposition Authors: Teng F , He ZX , Hu YQ , Xu CY, Guo RY, Zhou L

Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.

He Z, Teng F , Yang Y, Guo R, Wu M, Han F, Tian H, Wang J, Hu Y, Jiang Y, Zhang L, Xu C, Yang F, Zhou J, Zhang S, Letts JA, Zhou R, Zhou L
(2026) Nat Struct Mol Biol , 33 , 100 - 111

PUBMED: 41214295
DOI: doi:10.1038/s41594-025-01710-6
ISSN: 1545-9985

Grant Support:

Other government: ZJU100 Young Professor