EMD-60360
Cryo-EM map of respirasome closed state 1 bound by metformin and CoQ (SC-MetC1-ii), complex I proximal membrane arm focused
EMD-60360
Single-particle2.86 Å
Deposition: 31/05/2024Map released: 19/11/2025
Last modified: 04/02/2026
Sample Organism:
Sus scrofa
Sample: Respirasome closed state 1 bound by metformin and CoQ(alternative orientation)
Deposition Authors: Teng F
,
He ZX ,
Hu YQ ,
Xu CY,
Guo RY,
Zhou L
Sample: Respirasome closed state 1 bound by metformin and CoQ(alternative orientation)
Deposition Authors: Teng F
,
He ZX ,
Hu YQ ,
Xu CY,
Guo RY,
Zhou L
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
He Z,
Teng F ,
Yang Y,
Guo R,
Wu M,
Han F,
Tian H,
Wang J,
Hu Y,
Jiang Y,
Zhang L,
Xu C,
Yang F,
Zhou J,
Zhang S,
Letts JA,
Zhou R,
Zhou L
(2026) Nat Struct Mol Biol , 33 , 100 - 111
,
Yang Y,
Guo R,
Wu M,
Han F,
Tian H,
Wang J,
Hu Y,
Jiang Y,
Zhang L,
Xu C,
Yang F,
Zhou J,
Zhang S,
Letts JA,
Zhou R,
Zhou L
(2026) Nat Struct Mol Biol , 33 , 100 - 111
Grant Support: