Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-60350

Single-particle
3.31 Å
EMD-60350
3D View Gallery
Deposition: 30/05/2024
Map released: 26/02/2025
Last modified: 23/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-60350
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8zpn summary report (pdf.gz) Map and 8zpn FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM strucutre of CXCR4 complexed with antagonist AMD3100

EMD-60350

Single-particle
3.31 Å
EMD-60350
3D View Gallery
Deposition: 30/05/2024
Map released: 26/02/2025
Last modified: 23/07/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Lama glama
Sample: AMD3100-CXCR4-KOR-Nb6
Fitted models: 8zpn

Deposition Authors: Jiao HZ, Hu HL
Structural mechanisms underlying the modulation of CXCR4 by diverse small-molecule antagonists.
Sang X , Jiao H, Meng Q, Fang X, Pan Q, Zhou J, Qian T, Zhang W, Xu Y , An J, Huang Z, Hu H
(2025) PNAS , 122 , e2425795122 - e2425795122
PUBMED: 40063796
DOI: doi:10.1073/pnas.2425795122
ISSN: 1091-6490
ASTM: PNASA6
Grant Support: