EMD-60339

Single-particle
2.84 Å
EMD-60339
3D View Gallery
Deposition: 30/05/2024
Map released: 19/11/2025
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-60339
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
EMICSS annotations (xml)

Cryo-EM map of respirasome closed state 1 in the absence of biguanide (SC-ApoC), complex I peripheral arm focused

EMD-60339

Single-particle
2.84 Å
EMD-60339
3D View Gallery
Deposition: 30/05/2024
Map released: 19/11/2025
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Sus scrofa
Sample: Respirasome close state 1 in absence of biguanide

Deposition Authors: Teng F , He ZX , Hu YQ , Xu CY, Guo RY, Zhou L
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
He Z, Teng F , Yang Y, Guo R, Wu M, Han F, Tian H, Wang J, Hu Y, Jiang Y, Zhang L, Xu C, Yang F, Zhou J, Zhang S, Letts JA, Zhou R, Zhou L
(2026) Nat Struct Mol Biol , 33 , 100 - 111
PUBMED: 41214295
DOI: doi:10.1038/s41594-025-01710-6
ISSN: 1545-9985