EMD-60284
Respirasome open state 3 in presence of metformin (SC-MetO3)
EMD-60284
Single-particle3.24 Å
Deposition: 28/05/2024Map released: 19/11/2025
Last modified: 04/02/2026
Sample Organism:
Sus scrofa
Sample: Sus scrofa supercomplex I+III2+IV in the presence of metformin
Fitted models: 8zo8
Deposition Authors: Teng F
,
He ZX,
Hu YQ,
Xu CY,
Guo RY,
Zhou L
Sample: Sus scrofa supercomplex I+III2+IV in the presence of metformin
Fitted models: 8zo8
Deposition Authors: Teng F
,
He ZX,
Hu YQ,
Xu CY,
Guo RY,
Zhou L
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
He Z ,
Teng F ,
Yang Y ,
Guo R,
Wu M ,
Han F ,
Tian H ,
Wang J,
Hu Y ,
Jiang Y,
Zhang L,
Xu C,
Yang F ,
Zhou J ,
Zhang S ,
Letts JA ,
Zhou R ,
Zhou L
(2026) Nat Struct Mol Biol , 33 , 100 - 111
,
Teng F ,
Yang Y ,
Guo R,
Wu M ,
Han F ,
Tian H ,
Wang J,
Hu Y ,
Jiang Y,
Zhang L,
Xu C,
Yang F ,
Zhou J ,
Zhang S ,
Letts JA ,
Zhou R ,
Zhou L
(2026) Nat Struct Mol Biol , 33 , 100 - 111
Grant Support:
- Other government: ZJU100 Young Professor (China)