EMD-58649
DNA-bound POLQTaqChimera in complex with compound 41
EMD-58649
Single-particle3.2 Å
Deposition: 22/06/2026Map released: 04/11/2026
Last modified: 04/11/2026
Sample Organism:
synthetic construct
Sample: Chimera of PolQ and Taq polymerase bound to DNA and compound 41.
Deposition Authors: Shilliday F, Maia de Oliveira T
Sample: Chimera of PolQ and Taq polymerase bound to DNA and compound 41.
Deposition Authors: Shilliday F, Maia de Oliveira T
Discovery of a Novel Series of Benzimidazoles/Purines as Potent, Selective and Orally Active Inhibitors of the DNA Polymerase Activity of POLQ.
Barlaam B 
,
Akrap N,
Barratt D,
Bodnarchuk MS ,
Cadogan EB,
Caswell SJ,
Cook K,
Forment JV,
Gopalsamy A ,
Griffiths D,
Hughes C,
Lochhead PA ,
Longmire D,
Maia de Oliveira T,
Maresca M,
Moss JI,
Peng B,
Pflug A ,
Pike A ,
de Renty C ,
Shields JD,
Shilliday F,
Southgate H,
Stubbs CJ,
Talapatra SK,
Turner O,
Turner P,
Underwood E,
Vasalou C ,
Ware J,
Winlow P,
Winter-Holt JJ ,
Wrigley G,
Xue L,
Zhang J,
Zhang K
(2026) J Med Chem , 69 , 24443 - 24470
,
Akrap N,
Barratt D,
Bodnarchuk MS ,
Cadogan EB,
Caswell SJ,
Cook K,
Forment JV,
Gopalsamy A ,
Griffiths D,
Hughes C,
Lochhead PA ,
Longmire D,
Maia de Oliveira T,
Maresca M,
Moss JI,
Peng B,
Pflug A ,
Pike A ,
de Renty C ,
Shields JD,
Shilliday F,
Southgate H,
Stubbs CJ,
Talapatra SK,
Turner O,
Turner P,
Underwood E,
Vasalou C ,
Ware J,
Winlow P,
Winter-Holt JJ ,
Wrigley G,
Xue L,
Zhang J,
Zhang K
(2026) J Med Chem , 69 , 24443 - 24470
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