EMD-58529

Single-particle
5.5 Å
EMD-58529
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Deposition: 12/06/2026
Map released: 01/07/2026
Last modified: 01/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-58529
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CryoEM structure of a catalytically inactive CXC Chemokine-degrading protease SpyCEP from Streptococcus pyogenes complexed with an anti-N-terminal monoclonal antibody

EMD-58529

Single-particle
5.5 Å
EMD-58529
3D View Gallery
Deposition: 12/06/2026
Map released: 01/07/2026
Last modified: 01/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Mus musculus, Streptococcus pyogenes
Sample: SpyCEP complexed with 10B6C10

Deposition Authors: Lau RJ , Wu GHY , Barritt JD , Huemer CB , Matthews S
SpyCEP dismantles neutrophil immunity via disorder-driven chemokine remodeling and GAG targeting
Lau RJ , Giblin SP, Sugar A, Di Maio A, Tassini G, Huse K, Chorev D, Chen Y, Wu GHY , Huemer CB , Kim SY, Matthews J, Muloud B, Chen L, McKenna S, Xu Y, Massai L, Muzzi C, Ferhati X, Necchi F, Moriel DG, Feizi T, Liu Y, Pease JE, Sriskandan S, Matthews S
(2026) PNAS
Grant Support: