EMD-58529
CryoEM structure of a catalytically inactive CXC Chemokine-degrading protease SpyCEP from Streptococcus pyogenes complexed with an anti-N-terminal monoclonal antibody
EMD-58529
Single-particle5.5 Å
Deposition: 12/06/2026Map released: 01/07/2026
Last modified: 22/07/2026
Sample Organism:
Mus musculus,
Streptococcus pyogenes
Sample: SpyCEP complexed with 10B6C10
Deposition Authors: Lau RJ
,
Wu GHY ,
Barritt JD ,
Huemer CB ,
Matthews S
Sample: SpyCEP complexed with 10B6C10
Deposition Authors: Lau RJ
,
Wu GHY ,
Barritt JD ,
Huemer CB ,
Matthews S
SpyCEP dismantles neutrophil immunity via disorder-driven chemokine remodeling and GAG targeting.
Lau RJ ,
Giblin SP,
Sugar A,
Di Maio A,
Tassini G,
Huse K,
Chorev D,
Chen Y,
Wu GH,
Huemer CB ,
Kim SY,
Matthews J,
Muloud B,
Chen L,
McKenna S,
Xu Y,
Massai L,
Muzzi C,
Ferhati X,
Necchi F,
Gomes Moriel D,
Feizi T,
Liu Y,
Pease JE,
Sriskandan S,
Matthews S
(2026) PNAS , 123 , e2520164123 - e2520164123
,
Giblin SP,
Sugar A,
Di Maio A,
Tassini G,
Huse K,
Chorev D,
Chen Y,
Wu GH,
Huemer CB ,
Kim SY,
Matthews J,
Muloud B,
Chen L,
McKenna S,
Xu Y,
Massai L,
Muzzi C,
Ferhati X,
Necchi F,
Gomes Moriel D,
Feizi T,
Liu Y,
Pease JE,
Sriskandan S,
Matthews S
(2026) PNAS , 123 , e2520164123 - e2520164123
Grant Support:
- Medical Research Council (MRC, United Kingdom): UKRI682 (United Kingdom)