EMD-58422

Single-particle
7.76 Å
EMD-58422
3D View Gallery
Deposition: 05/06/2026
Map released: 21/10/2026
Last modified: 21/10/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-58422

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Complex of phospho-TDO2 with E3 ligase CUL1-bTrCP2

EMD-58422

Single-particle
7.76 Å
EMD-58422
3D View Gallery
Deposition: 05/06/2026
Map released: 21/10/2026
Last modified: 21/10/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Complex of phospho-TDO2 with E3 ligase CUL1-bTrCP2

Deposition Authors: Thielen AS , Schulman BA
A CK2-beta-TrCP kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating tryptophan 2,3-dioxygenase stability.
Thielen AS , Brauning B, Gottemukkala KV, Muller J, Prabu JR, Verma P, Klaessens S, Van den Eynde BJ, Kleiger G, Murray PJ, Schulman BA
(2026) Mol Cell
PUBMED: 42863465
DOI: doi:10.1016/j.molcel.2026.09.023
ISSN: 1097-2765
ASTM: MOCEFL
Grant Support: