EMD-57361
The complex of A1AT-NHK with the ERAD misfolded glycoprotein checkpoint complex from Chaetomium thermophilum (EDEM:PDI heterodimer).
EMD-57361
Single-particle3.46 Å
Deposition: 07/04/2026Map released: 24/06/2026
Last modified: 24/06/2026
Sample Organism:
Thermochaetoides thermophila,
Homo sapiens
Sample: Ternary complex of human A1AT-NH and Chaetomium thermophilum Endoplasmic reticulum degradation enhancing mannosidase (CtEDEM) plus Endoplasmic reticulum degradation enhancing protein disulfide isomerase (CtPDI)
Fitted models: 29te
Deposition Authors: Roversi P
,
Hitchman CJ ,
Gooptu B ,
Bhogadia M ,
Lia A
Sample: Ternary complex of human A1AT-NH and Chaetomium thermophilum Endoplasmic reticulum degradation enhancing mannosidase (CtEDEM) plus Endoplasmic reticulum degradation enhancing protein disulfide isomerase (CtPDI)
Fitted models: 29te
Deposition Authors: Roversi P
,
Hitchman CJ ,
Gooptu B ,
Bhogadia M ,
Lia A
Structure and function of the EDEM:PDI ERAD checkpoint complex
Hitchman CJ ,
Lia A ,
Chiritoiu GN,
Munteanu CVA,
Ortigosa JR,
Ghenea S,
Savva C,
Wada I,
De Benedictis M,
Tax G,
Bayo Y,
Crescioli I,
Alonzi DL,
Quigley A,
Modenutti CP,
Petrescu SM,
Santino A,
Gooptu B ,
Hosokawa N,
Roversi P
(2025) bioRxiv
,
Lia A ,
Chiritoiu GN,
Munteanu CVA,
Ortigosa JR,
Ghenea S,
Savva C,
Wada I,
De Benedictis M,
Tax G,
Bayo Y,
Crescioli I,
Alonzi DL,
Quigley A,
Modenutti CP,
Petrescu SM,
Santino A,
Gooptu B ,
Hosokawa N,
Roversi P
(2025) bioRxiv
Grant Support:
- Wellcome Trust: 204801/Z/16/Z (United Kingdom)
- Wellcome Trust: 214090/Z/18/Z (United Kingdom)
- Italian National Research Council (CNR): Plant_EDEM (Italy)
- Italian National Research Council (CNR): B53C22009060005 (Italy)