EMD-57361

Single-particle
3.46 Å
EMD-57361
3D View Gallery
Deposition: 07/04/2026
Map released: 24/06/2026
Last modified: 24/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-57361
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 29te summary report (pdf.gz) Map and 29te FULL report (pdf.gz)
EMICSS annotations (xml)

The complex of A1AT-NHK with the ERAD misfolded glycoprotein checkpoint complex from Chaetomium thermophilum (EDEM:PDI heterodimer).

EMD-57361

Single-particle
3.46 Å
EMD-57361
3D View Gallery
Deposition: 07/04/2026
Map released: 24/06/2026
Last modified: 24/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Thermochaetoides thermophila, Homo sapiens
Sample: Ternary complex of human A1AT-NH and Chaetomium thermophilum Endoplasmic reticulum degradation enhancing mannosidase (CtEDEM) plus Endoplasmic reticulum degradation enhancing protein disulfide isomerase (CtPDI)
Fitted models: 29te

Deposition Authors: Roversi P , Hitchman CJ , Gooptu B , Bhogadia M , Lia A
Structure and function of the EDEM:PDI ERAD checkpoint complex
Hitchman CJ , Lia A , Chiritoiu GN, Munteanu CVA, Ortigosa JR, Ghenea S, Savva C, Wada I, De Benedictis M, Tax G, Bayo Y, Crescioli I, Alonzi DL, Quigley A, Modenutti CP, Petrescu SM, Santino A, Gooptu B , Hosokawa N, Roversi P
(2025) bioRxiv
DOI: doi:10.1101/2025.01.29.635535
ISSN: 2692-8205