EMD-57308

Single-particle
5.87 Å
EMD-57308
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Deposition: 31/03/2026
Map released: 06/05/2026
Last modified: 06/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-57308
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EMICSS annotations (xml)

SKP1-FBXO22-UNC10088-NSD2 locally refined Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2 via UNC10415667

EMD-57308

Single-particle
5.87 Å
EMD-57308
3D View Gallery
Deposition: 31/03/2026
Map released: 06/05/2026
Last modified: 06/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: SCF FBXO22, NSD2, UNC10088

Deposition Authors: Amann SJ, Robertson KC, Grishkovskaya I, Liu T, James LI, Brown NB, Haselbach D
Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22.
Robertson KC, Amann SJ, Liu T, Funk AV, Wang X, Grishkovskaya I, Mehmood A, Tabor JR, Norris-Drouin JL, Arrowsmith CH, Collins JL, Miao Y, Emanuele MJ, Haselbach D, James LI, Brown NG
(2026) Nat Commun
PUBMED: 42026065
DOI: doi:10.1038/s41467-026-72235-9
ISSN: 2041-1723