EMD-57068

Single-particle
2.8 Å
EMD-57068
3D View Gallery
Deposition: 05/03/2026
Map released: 14/10/2026
Last modified: 14/10/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-57068

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-29by summary report (pdf.gz) Map-29by FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of human DHX9 in complex with ATX-968 and ADP.

EMD-57068

Single-particle
2.8 Å
EMD-57068
3D View Gallery
Deposition: 05/03/2026
Map released: 14/10/2026
Last modified: 14/10/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human DHX9 bound to ATX-968 and ADP.
Fitted models: 29by

Deposition Authors: Hallett ST, Silva STN, Le Bihan Y, Van Montfort R
Fragment-Based Discovery of Potent RNA-Competitive Inhibitors of the DEAH-Box RNA Helicase DHX8.
Read BJ, Ewens C, Gigante F, Thomas J, Felisberto-Rodrigues C, Alvarez Peres S, Tighe C, de Las Heras Ruiz E, Schiemann K, Malcolm AG, McAndrew PC, Stubbs M, Patani H, Costa HDS, Stoodley K, Pickard L, Busch M, Gunnell E, Silva S, Knopp A, Hallett ST, Augustin M, Lammens A, Carter M, Meniconi M, Ballarotto M, Ainsley J, Meister P, Sethi D, Burke R, Scarpino A, Le Bihan YV, Gradler U, Blagg J, Workman P, Clarke PA, Blum A, Esdar C, Bhalay G, van Montfort RLM
(2026) J Med Chem , 69 , 18277 - 18299
PUBMED: 42593941
DOI: doi:10.1021/acs.jmedchem.6c00732
ISSN: 0022-2623
ASTM: JMCMAR
Grant Support: