EMD-56538
Structure of the human two pore domain potassium ion channel TASK-3 L122V mutant (K2P9.1)
EMD-56538
Single-particle2.83 Å
Deposition: 02/02/2026Map released: 19/08/2026
Last modified: 19/08/2026
Sample Organism:
Homo sapiens
Sample: K2P9.1 L122V homodimer
Fitted models: 28iz
Deposition Authors: Hall PR
,
Rodstrom KEJ ,
Tucker SJ
Sample: K2P9.1 L122V homodimer
Fitted models: 28iz
Deposition Authors: Hall PR
,
Rodstrom KEJ ,
Tucker SJ
Equivalent gain-of-function variants in KCNK3 and KCNK9 and their contribution to distinct TASK K2P channelopathies.
Crowther KM ,
Jouen-Tachoire TRH,
Proks P ,
Hall PR ,
Veale EL ,
Sormann J ,
Rodstrom KEJ ,
Muller T ,
Wortmann SB ,
Barisic N ,
Hauser N ,
Salpietro V ,
Forsyth R ,
Williams L ,
Derrabi N ,
Bacino CA ,
Rosenfeld JA ,
Houlden H ,
Newstead S ,
Wright CF ,
Fasham J ,
Mathie AA ,
Maroofian R ,
Tucker SJ
(2026) J Gen Physiol , 158
,
Jouen-Tachoire TRH,
Proks P ,
Hall PR ,
Veale EL ,
Sormann J ,
Rodstrom KEJ ,
Muller T ,
Wortmann SB ,
Barisic N ,
Hauser N ,
Salpietro V ,
Forsyth R ,
Williams L ,
Derrabi N ,
Bacino CA ,
Rosenfeld JA ,
Houlden H ,
Newstead S ,
Wright CF ,
Fasham J ,
Mathie AA ,
Maroofian R ,
Tucker SJ
(2026) J Gen Physiol , 158
Grant Support:
- Biotechnology and Biological Sciences Research Council (BBSRC): BB/T002018/1 (United Kingdom)
- Biotechnology and Biological Sciences Research Council (BBSRC): BB/S008608/1 (United Kingdom)
- Medical Research Council (MRC, United Kingdom): MR/W017741/1 (United Kingdom)