EMD-55800
Integrin AlphaIIbBeta3 bound to Fab of the anti-HPA-1a antibody 26.4
EMD-55800
Single-particle2.64 Å
Deposition: 22/11/2025Map released: 10/06/2026
Last modified: 05/08/2026
Sample Organism:
Homo sapiens
Sample: Complex of integrin aIIbb3 ectodomains bound to the Fab 26.4
Fitted models: 9td2
Deposition Authors: de Pereda JM
,
Stam W ,
Gragera M ,
van der Meer F ,
Chichon FJ ,
Zarkadas E ,
van der Schoot E ,
Vidarsson G ,
Takagi J ,
Margadant C
Sample: Complex of integrin aIIbb3 ectodomains bound to the Fab 26.4
Fitted models: 9td2
Deposition Authors: de Pereda JM
,
Stam W ,
Gragera M ,
van der Meer F ,
Chichon FJ ,
Zarkadas E ,
van der Schoot E ,
Vidarsson G ,
Takagi J ,
Margadant C
High-resolution cryo-EM structure of integrin alpha IIb beta 3 bound to disease-causing maternal HPA-1a antibody that blocks integrin activation.
de Pereda JM ,
Stam W ,
Gragera M ,
van der Meer F ,
Chichon FJ ,
Zarkadas E ,
van der Schoot E ,
Vidarsson G ,
Takagi J ,
Margadant C
(2026) Sci Adv , 12 , eaed9833 - eaed9833
,
Stam W ,
Gragera M ,
van der Meer F ,
Chichon FJ ,
Zarkadas E ,
van der Schoot E ,
Vidarsson G ,
Takagi J ,
Margadant C
(2026) Sci Adv , 12 , eaed9833 - eaed9833
Grant Support:
- Other private: 2019 (Netherlands)
- Other private: 2336 (Netherlands)
- Agencia Estatal de Investigacion (AEI): PID2022-136322NB-I00 (Spain)
- Other government: 34459 (European Union)
- Other government: 37638 (European Union)
- Other government: 68606 (European Union)