EMD-55784

Single-particle
2.77 Å
EMD-55784
3D View Gallery
Deposition: 20/11/2025
Map released: 04/11/2026
Last modified: 04/11/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-55784

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM focused map of the active-state GPR55-N171Q mutant in complex with G13 and BI-6229

EMD-55784

Single-particle
2.77 Å
EMD-55784
3D View Gallery
Deposition: 20/11/2025
Map released: 04/11/2026
Last modified: 04/11/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: GPR55-N171Q-G13-ScFv16-BI-6229

Deposition Authors: Claff T , Ebenhoch R , Kley JT , Weichert D
Molecular insights into GPR55 modulation reveal an atypical activation mechanism and glycosylation-dependent efficacy regulation.
Claff T , Demalgiriya-Gamage C, Mahardhika AB, Stamos NA, Bangnowski F, Sun X, Durr KL, Robinson CV, Haney R, Frego L, Nar H, Muller CE, Ebenhoch R , Kley JT , Weichert D
(2026) Nat Commun , 17
PUBMED: 42926240
DOI: doi:10.1038/s41467-026-78538-1
ISSN: 2041-1723
Grant Support: